testosterone enanthate vs cypionate
The initial dose is 200-400 mg per day. Its is slowly raised until the disappearance of pain (typically up to a dose of 200 mg 3-4 times a day). Then the dose is gradually reduced to the minimum maintenance.
The recommended initial dose for elderly patients is 100 mg 2 times a day. Alcohol withdrawal syndrome Average dosage is 200 mg 3 times a day. In severe cases, during the first few days, the dose may be increased (e.g., up to a dose of 400 mg three times a day). In testosterone enanthate vs cypionate severe forms of alcohol withdrawal, treatment begins with the use of the drug in combination with drugs that have a sedative and hypnotic action (for example, clomethiazole, chlordiazepoxide). After resolution of the acute phase treatment with the drug can be continued as monotherapy. Polyuria and polydipsia of neurohormonal nature with central diabetes insipidus The average dose for adults is 200 mg 2-3 times a day. In children, the dose should be reduced according to the age and body weight of the child. Pain diabetic neuropathyaverage dose of 200 mg 2-4 times a day. Acute mania and maintenance treatment of affective (bipolar) disorder daily dose is 400 1600 mg. The average daily dose – 400-600 mg (2-3 hours). In acute manic state dose should be increased rather quickly. With each successive increase in the dose maintenance therapy of bipolar disorders in order to ensure optimal tolerability should be small, the daily dose is increased gradually.
Certain types of adverse reactions, such as the central nervous system (dizziness, headache, ataxia, drowsiness, fatigue, diplopia), the part of the digestive system (nausea, vomiting), and allergic skin reactions occur very often or often, especially at the beginning of treatment, or using too high an initial dose of the drug or the treatment of elderly patients.
dose-dependent side effects usually disappear within several days, both spontaneously and following a temporary dose reduction. The development of side reactions of the testosterone enanthate vs cypionatemay be due to relative overdosing or significant, the oscillation of the active substance in the blood plasma. In such cases it is advisable to monitor the concentration of the active substance in the blood plasma.
In evaluating the frequency of occurrence of various adverse reactions following grading used: including isolated reports. Psychiatric disorders : rarely hallucinations (visual or auditory ), depression, anorexia, restlessness, aggression, agitation, disorientation; very rarely – activation of psychosis. From the nervous system : very often – dizziness, ataxia, drowsiness, fatigue; often – headache, diplopia, accommodation disturbances of vision (eg blurred vision); sometimes – abnormal involuntary movements (eg tremor, “fluttering” tremor / asterixis /, muscular dystonia, tics); nystagmus; rare – orofacial dyskinesia, oculomotor disturbances, speech disorders (eg, dysarthria), choreoathetosis, peripheral neuropathy, paresthesia, paresis; very seldom – taste disturbances, neuroleptic malignant syndrome.
On the part of the skin and its appendages : very often – allergic dermatitis, urticaria, which may be significantly pronounced; sometimes exfoliative dermatitis, erythroderma; rare – systemic lupus erythematosus, pruritus; very rarely – Stevens-Johnson syndrome, toxic epidermal necrolysis, photosensitivity reactions, erythema multiforme and nodosum, skin pigmentation disorders, purpura, acne, sweating, hair loss. It was reported about rare cases of hirsutism, but the causal relationship of this complication with a drug intake remains unclear. From the hematopoietic system : very often – leukopenia; often -trombotsitopeniya, eosinophilia; -leykotsitoz rarely, lymphadenopathy, folic acid deficiency; very rarely agranulocytosis; aplastic anemia, pancytopenia, anemia, pure red cell aplasia, megaloblastic anemia, variegated porphyria, late cutaneous porphyria, acute intermittent porphyria, reticulocytosis, and possibly haemolytic anemia.
During the administration of the drug may develop agranulocytosis, and aplastic anemia. However, due to the fact that these conditions are very rare, it is difficult to quantify the risk of their occurrence. It is known that the overall risk of agranulocytosis in the general population who are not receiving treatment, is 4.7 cases per 1 million population per year, and aplastic anemia – 2.0 cases per 1 million population per year… From the digestive system : very often – nausea, vomiting; -suhost often in the mouth; sometimes – diarrhea, constipation; rare – abdominal pain; rarely -glossit, stomatitis, pancreatitis. On the part of the hepatobiliary system : very often – increase the level of gamma-glutamintransferazy (due to induction of this enzyme in the liver), which usually has no clinical significance; often – increased alkaline phosphatase blood; sometimes testosterone enanthate vs cypionate – transaminase elevation; rarely – hepatitis cholestatic, parenchymal (hepatocellular) or mixed type, jaundice; rarely granulomatous hepatitis, hepatic failure. hypersensitivity reactions : seldom – multiorgan delayed type hypersensitivity with fever, skin rashes, vasculitis, lymphadenopathy, symptoms resembling lymphoma, arthralgia, leukopenia, eosinophilia, hepatosplenomegaly and altered liver function tests (these symptoms occur in different combinations).
There may also be involved other organs (eg, lungs, kidneys, pancreas, myocardium, colon); very rarely – aseptic meningitis with myoclonus and peripheral eosinophilia; anaphylactic reaction angioedema. In the event of hypersensitivity reactions of the above-mentioned use of the drug should be discontinued. Since the cardiovascular system : rarely – a violation of intracardiac conduction; increase or decrease in blood pressure; very rarely – bradycardia, arrhythmias, AV block with syncope, circulatory collapse, congestive heart failure, aggravation of coronary artery disease, thrombophlebitis, thromboembolism (eg pulmonary embolism).
On the part of the endocrine system : often – edema, fluid retention, weight gain , hyponatremia and decreased blood osmolarity due to an effect similar to the action of antidiuretic hormone, which in rare cases leads to water intoxication (hyponatremia dilution), accompanied by lethargy, vomiting, headache, disorientation and neurological disorders; very rare – increase in blood prolactin levels, accompanied or not by such manifestations as the galactorrhea, gynecomastia; Changes in thyroid function decline in L-thyroxine (free thyroxine, thyroxine, triiodothyronine) and increase the level of thyroid-stimulating hormone, which is usually not accompanied by clinical symptoms; disorders of bone metabolism (decrease in calcium levels and 25-hydroxy-kolekaltsiferola in the blood), which leads to osteomalacia / osteoporosis; increasing the concentration of cholesterol including cholesterol HDL, and triglycerides. From the urogenital system : very rarely – interstitial nephritis, renal failure, renal impairment (eg albuminuria, haematuria, oliguria, increase in urea / azotemia), urinary frequency, urinary retention , sexual dysfunction / impotence, spermatogenesis disorders (decrease in sperm count and motility). From the sensory organs : rarely testosterone enanthate vs cypionate taste sensations, cataract, conjunctivitis, increased intraocular pressure; hearing disorders, including tinnitus, hyperacusis, Gipoakuzija, changes in the perception of pitch. From the musculoskeletal system : rare muscle weakness, very rarely – arthralgia, muscle pain or cramps. The respiratory system : very rarely – hypersensitivity reactions, characterized by fever, dyspnoea , pneumonitis or pneumonia. Change lab results : very rarely hypogammaglobulinemia.