testosterone cypionate side effects

Absorption – rapid and complete (meal slows down).  The maximum concentration observed after 2 hours. Tenoxicam distinctive feature is the long duration of action and a long half-life – 72 hours. The drug is 99% bound to plasma proteins. Tenoxicam well into the synovial fluid.Easily penetrates the blood-tissue barriers. It is metabolized in the liver by hydroxylation to form a 5-gidroksitenoksikama. 1/3 is excreted in the bile, 2/3 in the urine as inactive metabolites.

Indications
Rheumatoid arthritis, osteoarthritis, ankylosing testosterone cypionate side effects spondylitis, articular syndrome in exacerbation of gout, bursitis, tenosynovitis; pain (mild to moderate intensity): arthralgia, myalgia, neuralgia, migraine, toothache and headache, tuberculosis; pain with injuries, burns.

Contraindications:
Hypersensitivity, erosive and ulcerative lesions of the gastrointestinal tract (including history), gastrointestinal bleeding (including history), gastritis, severe course, “Aspirin” triad, hemophilia, anticoagulation, liver and / or kidney failure, hearing loss, vestibular pathology, deficiency of glucose-6-phosphate dehydrogenase;blood diseases, pregnancy, lactation, age 18 years.

With care – heart failure, edema, hypertension, diabetes, advanced age.

Dosing and Administration Inside . 20 mg (1 tablet) 1 times a day, after a meal (preferably at the same time;. With prolonged use – 10mg per day in acute attacks of gout – 40 mg 1 time per day for the first two days; then switching to 1 20 mg once daily for another 5 days. Older patients are administered in a dose of 20 mg / day.

Side effects From the digestive system : dyspepsia (nausea, vomiting, heartburn, diarrhea, flatulence), NSAID-gastropathy, abdominal pain, stomatitis, anorexia, abnormal liver function. With prolonged use at high doses – ulceration of the mucosa of the gastrointestinal tract testosterone cypionate side effects, bleeding (gastrointestinal, gingival, uterine, hemorrhoids), perforation of the bowel wall. Cardio-vascular system : congestive heart failure, tachycardia, increased blood pressure. From the nervous system : headache, dizziness, somnolence, depression, agitation, decreased hearing, tinnitus, eye irritation, blurred vision. From the side of hematopoiesis : agranulocytosis, leukopenia, rarely -anemiya, thrombocytopenia. Allergic reactions : skin rash, pruritus, urticaria, angioedema, Stevens-Johnson syndrome and toxic epidermal necrolysis. Laboratory findings : hypercreatininemia, hyperbilirubinemia, increased urea nitrogen concentration and the activity of “liver” transaminases, prolonged bleeding time. Other : bronchospasm, impaired renal function, increased sweating, edema syndrome ( including periorbital edema).

 

Overdose
If overdose is necessary symptomatic treatment.

Cautions
During treatment necessary to monitor patterns of peripheral blood and functional state of the liver and kidneys, prothrombin index (against the background of indirect anticoagulants), blood glucose (in the background of oral hypoglycemic agents).
If necessary, the definition of 17-keto steroids, the drug should be discontinued for 48 hours prior to the study.
in just a few days before surgery, cancel drug.
in the period of treatment should refrain from activities potentially hazardous activities that require high concentration and psychomotor speed reactions.
It is necessary to consider the possibility of a delay of sodium and water in the body in the appointment of diuretics in patients with hypertension and cardiac insufficiency.
a history of kidney disease can lead to interstitial nephritis, papillary necrosis and nephrotic syndrome, without nephrotoxic drugs applied directly after surgery.

The interaction
Inductors of microsomal oxidation in the liver testosterone cypionate side effects (phenytoin, ethanol, barbiturates, ziksorin, rifampin, phenylbutazone, tricyclic antidepressants) increase the production of hydroxylated active metabolites.
Reduces the uricosuric drugs, increases the effects of anticoagulants, antiplatelet agents, fibrinolytic agents, side effects mineralokortikosteroidov, steroids, estrogen; reduces the effectiveness of antihypertensive and diuretics; enhances the hypoglycemic effect of sulfonylureas.
antacids and cholestyramine reduce the absorption.
Increases blood concentration of drugs lithium, methotrexate.
Other testosterone cypionate side effects – the risk of side effects, particularly on the part of the digestive tract.