Inside, cypionate testosterone regardless of meals. The recommended daily dose is 1 tablet daily in the morning.
The maximum reduction in blood pressure in the majority of patients achieved within 2-3 weeks of treatment. The maximum . No dose adjustment is required for elderly patients and patients with impaired hepatic function.
For patients with moderate renal impairment (creatinine clearance less than 60 mL / min.), The daily dose should not exceed 600 mg.
The duration of the drug is not restricted.
most often in patients treated with eprosartan, reported such pobochnk drug reactions, such as headache and non-specific complaints on the state of the digestive system, occurs in about 11% and 8% of patients, respectively.
On the part of the central nervous system: very often – headache, often – dizziness, asthenia. Cardio-vascular system: seldom – a marked reduction in blood pressure. For the skin and subcutaneous fat:often – allergic skin reactions (eg, skin rash, itching), rarely – angioedema (including the face, lips, tongue, pharynx). from the digestive system: often – non-specific complaints on the part of the gastrointestinal tract (eg, nausea, diarrhea, vomiting). immune system: rarely – hypersensitivity. with the genitourinary system: renal function, including acute renal failure, especially in patients at risk (eg renal artery stenosis).
Limited data are available on overdose. The drug was well tolerated by ingestion.
Symptoms: marked reduction of blood pressure.
Treatment: symptomatic therapy.
Interaction with other drugs
Eprosartan does not affect the pharmacokinetics cypionate testosterone of digoxin and the pharmacodynamics of warfarin or glibenclamide.
Ranitidine, ketoconazole, fluconazole not affect the pharmacokinetics of eprosartan. Eprosartan can be used in combination with a thiazide diuretic (including hydrochlorothiazide) blockers and “slow” calcium channels, including nifedipine sustained action without waiting for clinically significant adverse interactions with the mutual strengthening hypotensive effect.
Teveten may be administered simultaneously with lipid-lowering agents (including lovastatin, simvastatin, pravastatin, fenofibrate, gemfibrozil and nicotinic acid in the lipid-lowering doses).
There are cases of reversible increase the concentration of lithium in blood serum and the development of toxic reactions while receiving lithium drugs with inhibitors . We can not exclude the possibility of a similar effect after administration of eprosartan, therefore we recommend monitoring the concentration of lithium in blood plasma while taking eprosartan.
in patients with reduced , while limiting salt consumption during prolonged and repeated vomiting, can cause the development of symptomatic hypotension. Before starting treatment is necessary to correct .
Renal failure, severe chronic heart failure
patients whose renal function is dependent on the activity (eg, with severe chronic heart failure cypionate testosteronefunctional class classification, bilateral renal artery stenosis or stenosis of the artery to a solitary kidney) during treatment inhibitors may develop oliguria and / or progressive azotemia, and in rare cases, severe renal insufficiency.
Due to the lack of experience of application of angiotensin II receptor antagonists in patients with severe chronic heart failure or renal artery stenosis of a solitary kidney, it is impossible to eliminate violations of renal function during treatment , as a result suppression.
Before assigning Teveten drug to patients with renal failure and periodically during the course of therapy should monitor renal function. If during this period there is deterioration of renal function should be reconsidered the need to continue treatment.
Effects on ability to vehicles driving or control mechanisms that require attention
Based on the pharmacodynamic properties cypionate testosterone of eprosartan, the drug should not affect the ability to manage or use of motor vehicles and machinery.
During treatment with Teveten should be careful when driving and other lesson potentially dangerous activities which require high concentration and psychomotor speed reactions, due to the possibility of dizziness and weakness.